$ sudo gem install rsruby -- --with-R-home=/usr/lib/R --with-R-include=/usr/share/R/include --with-R-dir=/Library/Frameworks/R.framework/Resources/
After installation setup the R_HOME global variable
export R_HOME=/usr/bin/R
At IRB
>> require 'rsruby' => true >> RSRuby.instance cannot find system Renviron Fatal error: unable to open the base package